Radiolab produce fascinating podcasts that explore any number of subjects in a non-pretentious and mind-bending way. I've been a huge fan for a long time and not enough people know about them.
Their most recent episode is focusing on the subject of sports, why do we care so much about the result of a trivial game?
There are some amazing stories in there, theories and experiments... And I highly recommend people to check it out. If you love the format as much as I do, check out the rest. There's a ton of them and they are completely free.
(They may be available on iTunes as well, someone confirm?)